Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020

Background Early-life cardiovascular risk factors (CVRFs) are known to be associated with target organ damage during adolescence and premature cardiovascular morbidity and mortality during adulthood. However, contemporary data describing whether the prevalence of CVRFs and treatment and control rates have changed are limited. This study aimed to examine the temporal trends in the prevalence, treatment, and control of CVRFs among US adolescents over the past 2 decades. Methods This is a serial cross-sectional study using data from nine National Health and Nutrition Examination Survey cycles (January 2001—March 2020). US adolescents (aged 12 to 19 years) with information regarding CVRFs (including hypertension, elevated blood pressure [BP], diabetes, prediabetes, hyperlipidemia, obesity, overweight, cigarette use, inactive physical activity, and poor diet quality) were included. Age-adjusted trends in CVRF prevalence, treatment, and control were examined. Joinpoint regression analysis was performed to estimate changes in the prevalence, treatment, and control over time. The variation by sociodemographic characteristics were also described. Results A total of 15,155 US adolescents aged 12 to 19 years (representing ≈ 32.4 million people) were included. From 2001 to March 2020, there was an increase in the prevalence of prediabetes (from 12.5% [95% confidence interval (CI), 10.2%-14.9%] to 37.6% [95% CI, 29.1%-46.2%]) and overweight/obesity (from 21.1% [95% CI, 19.3%-22.8%] to 24.8% [95% CI, 21.4%-28.2%]; from 16.0% [95% CI, 14.1%-17.9%] to 20.3% [95% CI, 17.9%-22.7%]; respectively), no improvement in the prevalence of elevated BP (from 10.4% [95% CI, 8.9%-11.8%] to 11.0% [95% CI, 8.7%-13.4%]), diabetes (from 0.7% [95% CI, 0.2%-1.2%] to 1.2% [95% CI, 0.3%-2.2%]), and poor diet quality (from 76.1% [95% CI, 74.0%-78.2%] to 71.7% [95% CI, 68.5%-74.9%]), and a decrease in the prevalence of hypertension (from 8.1% [95% CI, 6.9%-9.4%] to 5.5% [95% CI, 3.7%-7.3%]), hyperlipidemia (from 34.2% [95% CI, 30.9%-37.5%] to 22.8% [95% CI, 18.7%-26.8%]), cigarette use (from 18.0% [95% CI, 15.7%-20.3%] to 3.5% [95% CI, 2.0%-5.0%]), and inactive physical activity (from 83.0% [95% CI, 80.7%-85.3%] to 9.5% [95% CI, 4.2%-14.8%]). Sex and race/ethnicity affected the evolution of CVRF prevalence differently. Whilst treatment rates for hypertension and diabetes did not improve significantly (from 9.6% [95% CI, 3.5%-15.8%] to 6.0% [95% CI, 1.4%-10.6%]; from 51.0% [95% CI, 23.3%-78.7%] to 26.5% [95% CI, 0.0%-54.7%]; respectively), BP control was relatively stable (from 75.7% [95% CI, 56.8%-94.7%] to 73.5% [95% CI, 40.3%-100.0%]), while glycemic control improved to a certain extent, although it remained suboptimal (from 11.8% [95% CI, 0.0%-31.5%] to 62.7% [95% CI, 62.7%-62.7%]). Conclusions From 2001 to March 2020, although prediabetes and overweight/obesity increased, hypertension, hyperlipidemia, cigarette use, and inactive physical activity decreased among US adolescents aged 12 to 19 years, whereas elevated BP, diabetes, and poor diet quality remained unchanged. There were disparities in CVRF prevalence and trends across sociodemographic subpopulations. While treatment and control rates for hypertension and diabetes plateaued, BP control were stable, and improved glycemic control was observed. Supplementary Information The online version contains supplementary material available at 10.1186/s12916-024-03453-5.


Background
Cardiovascular diseases (CVDs) have been the leading cause of deaths and disabilities for several decades [1].Despite substantial declines in cardiovascular mortality since 1950, CVDs remain the most common source of mortality in the US and accounts for up to 928,741 deaths in 2020 [2].CVDs are estimated to result in direct and indirect costs of over $407.3 billion between 2018 and 2019, constituting a considerable economic and social burden [3].
The primary purpose of this study was to determine how CVRF prevalence changed among US adolescents aged 12 to 19 years in the past 2 decades.A secondary purpose was to determine whether CVRF treatment and control rates were improved or deteriorative during this period, and whether these trends varied across sociodemographic subgroups.To achieve these goals, data from 9 cycles of the National Health and Nutrition Examination Survey (NHANES) were analyzed.

Data collection
The NHANES, administered by the National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC), comprises a series of publicly available, cross-sectional, nationwide surveys of civilian, noninstitutionalized US population [27,28].To obtain nationally representative estimates, the NHANES selects participants aged 1 to 80 years using a complex, multistage, probability sampling design.Most questionnaire data are collected through in-home interviews, and physical examinations and laboratory testing data are collected through mobile examinations; the data are released every 2 years since 1999.Details regarding design, weighting, and methodology have been described elsewhere [29].This study included 9 cycles from 2001-2002 to 2017-March 2020, focusing on participants aged 12-19 years.Among the adolescent participants, unweighted response rates ranged from 54.4% to 88.9% for in-home interviews and 50.7% to 86.4% for mobile examinations (Additional file 1: eTable 1).The NCHS Ethics Review Board approved the study protocol, and written informed consent was acquired from all individuals [30].The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline was followed throughout the study (Additional file 1: eTable 2) [31].
During the in-home interviews, information regarding age, sex, race/ethnicity, educational level, income to poverty ratio (IPR), insurance status, and medical conditions (including medical history and medication use) was collected.Race/ethnicity categories included non-Hispanic White, non-Hispanic Black, Mexican American, and other races/ethnicities (including other Hispanic and other/multiple races or ethnicities).Medical history and medication use were self-reported.Medication use was determined by the responses to questions about taking prescription drugs.Participants who answered 'yes' were asked to show all drug containers; when not available, participants were asked to verbally list all drug names.
Participants were asked whether they had ever smoked cigarettes, how old they were when they first smoked, and whether they smoked during the past month to determine smoking status.Participants were also asked to report the frequency and duration of moderate-and, separately, vigorous-intensity physical activity (including work-and transportation-related and leisure-time domains) during a typical week.Weekly exercise time was calculated as the minutes of moderate-intensity physical activity plus twice the minutes of vigorousintensity physical activity per week.Dietary information was obtained from 24-h recall interviews during the mobile examinations.The simple Healthy Eating Index-2015 (HEI-2015) scoring algorithm (per day), based on 13 dietary components (including total fruit, whole fruit, total vegetables, greens or beans, whole grains, dairy, total protein foods, seafood or plant protein, fatty acids, refined grains, sodium, added sugars, and saturated fat), was used to indicate overall diet quality [32].Anthropometry parameters including weight, height, and BP were measured using standard protocols.Body mass index (BMI) was calculated by dividing weight by height squared.Systolic and diastolic BP were calculated as the mean of 3 (sometimes 4) BP determinations.
Non-fasting laboratory testing was used to measure serum levels of hemoglobin A 1c (HbA 1c ), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C).The non-high-density lipoprotein cholesterol (non-HDL-C) was calculated by subtracting HDL-C from TC.Approximately half of the participants were sampled to attend a morning examination, during which fasting plasma glucose (FPG), low-density lipoprotein cholesterol (LDL-C), and triglycerides levels were measured after fasting for 8.5 to less than 24 h.

Assessment of CVRF prevalence, treatment, and control
The prevalence of CVRFs was evaluated through the above parameters derived from in-home interviews and mobile examinations.According to the 2017 American Academy of Pediatrics and 2017 American College of Cardiology/American Heart Association guidelines [33,34], age-, sex-, and height-specific BP percentiles and 130/80 mmHg were used to define high BP in adolescents aged < 18 and 18-19 years, respectively (Additional file 1: eTable 3).Hypertension was defined as stage 1 or 2 levels and/or current use of antihypertensive medications (Additional file 1: eMethod 1), whereas elevated BP was defined as an elevated level.Diabetes was defined as a HbA 1c of ≥ 6.5%, FPG of ≥ 126 mg/dL, self-report of previous diagnosis, and/or current use of antidiabetic medications, whereas prediabetes was defined as a HbA 1c of 5.7%-6.4% and/or FPG of 100-125 mg/dL [35].Hyperlipidemia was defined as a TC of ≥ 200 mg/ dL, HDL-C of < 40 mg/dL, non-HDL-C of ≥ 145 mg/dL, LDL-C of ≥ 130 mg/dL, triglycerides of ≥ 130 mg/dL, and/or current use of antihyperlipidemic medications [36,37].Obesity and overweight were defined based on BMI using the Lambda Mu Sigma method [38].In accordance with CDC's standard [39,40], cigarette use was defined as smoking cigarettes within the previous 30 days.Based on the 2018 Physical Activities Guidelines for Americans [41], inactive physical activity was defined as a weekly exercise time of < 420 and < 150 min/wk in adolescents aged < 18 and 18-19 years, respectively.Diet quality was broadly classified according to HEI-2015, and a score of < 51 points was considered as poor diet quality [42].Consistent definitions were applied for the CVRFs throughout the study.
CVRF treatment and control rates were also assessed in adolescents aged 12-19 years.Hypertension treatment was defined as current use of antihypertensive medications.Hypertension was considered controlled if (1) BP was reduced to < 90th percentile in adolescents aged < 13 years, (2) BP was reduced to < 90th percentile and < 130/80 mmHg in adolescents aged 13-17 years, or (3) BP was reduced to < 130/80 mmHg in adolescents aged 18-19 years [33,34].Diabetes treatment was defined as current use of antidiabetic medications.Diabetes was considered controlled if HbA 1c was reduced to < 7% [43,44].Hyperlipidemia treatment and control rates were not analyzed because the updated guidelines no longer recommended lipid-level targets for treatment and the number of adolescents receiving lipid-lowering medications was small [36,37].

Statistical analysis
To ensure that the estimates accurately represented the noninstitutionalized US population, weights for the interview sample, examination sample, fasting subsample, and dietary sample were appropriately used for all analyses.Baseline characteristics of adolescents aged 12-19 years were presented as means or proportions with 95% confidence intervals (CIs).A linear trend in the weighted means and proportions over time was tested using F test based on weighted linear regression or Wald test based on logistic regression, with time treated as a continuous variable.Estimates for the prevalence, treatment, and control of CVRF were age-adjusted to the 2000 Census population, using the age groups of 12 to 14, 15 to 17, and 18 to 19 years.We calculated relative % change per 4-year cycle and P for trend using a joinpoint regression model with heteroscedastic and uncorrected errors, as previously described [26,45].The default maximum number of joinpoints (0 joinpoints, corresponding to a straight line) was allowed to avoid possible overfitting.The optimal fitting model was chosen by performing 4499 permutation tests based on the Monte Carlo method, adjusting for multiple tests.Parameters were estimated using weighted least squares, with weights proportional to the inverse of the variance of ln-transformed age-standardized prevalence rate at each 4-year cycle.Furthermore, logistic regression analyses were conducted, adjusting for age, sex, and race/ethnicity, to identify factors associated with the prevalence, treatment, and control of CVRFs.
To assess clinical implications of the updated guidelines for high BP on the prevalence, treatment, and control of high BP among adolescents, we also performed a sensitivity analysis by defining hypertension and elevated BP following the 2003 National Institutes of Health's National Heart, Lung, and Blood Institute (NIH/NHLBI) and 2004 NIH/NHLBI guidelines (Additional file 1: eTable 3) [46,47].The definition of hypertension treatment was identical to that used in the main analysis.Hypertension was considered controlled if (1) BP was reduced to < 95th percentile in adolescents aged < 18 years or (2) BP was reduced to < 140/90 mmHg in adolescents aged 18-19 years [46,47].
All analyses were performed using R software 4.2.3 (R Foundation) and Joinpoint Regression Program 5.0.2 (National Cancer Institute).A two-sided P-value of less than 0.05 was considered statistically significant.
Table 1 presents the descriptive characteristics of the individuals stratified by survey periods.The mean age was 15.4 years, and 51.3% were boys.The racial and ethnic distribution was as follows: 57.4% non-Hispanic White, 14.4% non-Hispanic Black, 13.3% Mexican American, and 14.9% from other races/ethnicities; over time, the proportions of Mexican Americans and other races/ ethnicities increased significantly (P for trend = 0.02 and < 0.001, respectively), whereas the proportion of non-Hispanic Whites decreased (P for trend < 0.001).The proportions of individuals who were born outside the US varied from 7.3% to 10.1%, and those who lived in poverty from 28.5% to 32.3%.The proportions of individuals with health insurance increased from 85.5% in 2001-2004 to 91.8% in 2017-March 2020 (P for trend < 0.001).
Compared with earlier years, individuals in the recent survey cycles were more likely to have normal diastolic BP, improved lipid profiles (including TC, HDL-C, non-HDL-C, LDL-C, and triglycerides), more exercise time, and an increased HEI-2015 score, but were prone to a higher BMI, increased HbA 1c level, and impaired fasting glucose.Age-adjusted trends in mean BP, HbA 1c , FPG, TC, HDL-C, non-HDL-C, LDL-C, triglycerides levels, BMI, weekly exercise time, and HEI-2015 for all individuals and pivotal subgroups (age and race/ethnicity) are displayed in Additional file 1: eFigures 2-4 and eTable 4.

CVRF prevalence rates
The prevalence rates of CVRFs among adolescents aged 12-19 years are summarized for age-adjusted analysis in Table 2 and for demographics-adjusted analysis in Table 3, and the secular trends are summarized in Additional file 1: eTable 4.
The adjusted prevalence of hypertension or elevated BP was higher among older individuals, boys, and non-Hispanic Blacks; individuals who were Mexican American, who were born outside the US, or who were from high-income families were less likely to have hypertension.Mexican Americans were more likely to have both diabetes and prediabetes; the adjusted prevalence of prediabetes was also higher among boys, while being lower among older individuals.Hyperlipidemia was more likely among older individuals and boys, and was less likely among non-Hispanic Blacks and affluent individuals.Obesity and overweight were more common among Mexican Americans, while being less common among non-US-born or affluent individuals; older individuals and non-Hispanic Blacks were also more likely to have obesity.The adjusted prevalence of cigarette use correlated positively with being older and male, while it correlated negatively with being non-Hispanic Black, Mexican American, or the other racial/ethnic group, coming from middle-or high-income families, and having health insurance.Inactive physical activity was more likely among non-Hispanic Blacks or Mexican Americans and non-US-born individuals, and was less likely among older individuals and boys.The adjusted prevalence of poor diet quality was higher among boys, while it was lower among individuals who were Mexican American or the other racial/ethnic group, who were born outside the US, or who were from high-income families.
Treatment and control rates for hypertension and diabetes by age and race/ethnicity were not evaluated due to limited sample size.

Discussion
Between 2001 and March 2020, prediabetes and overweight/obesity increased among US adolescents aged 12-19 years, while hypertension, hyperlipidemia, cigarette use, and inactive physical activity decreased, and elevated BP, diabetes, and poor diet quality did not change markedly.Boys experienced a higher prevalence of hypertension, elevated BP, prediabetes, hyperlipidemia, cigarette use, and poor diet quality, and a lower prevalence of inactive physical activity than girls.Furthermore, among racial/ethnic groups, non-Hispanic Whites had a significant decrease in hyperlipidemia, while an increase in diabetes was seen among non-Hispanic Blacks.Mexican Americans had a significant decrease in hyperlipidemia, but also an increase in overweight/obesity, while a decrease in hypertension was seen in the other racial/ ethnic group.Trends in the prevalence of elevated BP, prediabetes, cigarette use, inactive physical activity, and poor diet quality were generally similar across racial/ ethnic groups.Whilst treatment rates for hypertension and diabetes did not show improvement over time, BP control remained relatively stable, and there were some improvements in glycemic control, although it remained suboptimal.
The increase in overweight/obesity prevalence (to 24.8% and 20.3%, respectively) among adolescents was consistent with that previously observed [48][49][50][51].This rise in overweight/obesity rates may have a negative impact on public health and healthcare budgets because obesity is strongly correlated with other CVRFs such as hypertension, diabetes, and hyperlipidemia, which could result in premature CVDs and cardiovascular death during adulthood [13,16,[52][53][54].Several factors may contribute to the increase in overweight/obesity prevalence, including larger food portion sizes, consumption of energy-dense, nutrient-poor foods, changing modes of transportation, and sedentary behaviors [55][56][57][58].The prevalence of prediabetes increased from 12.5% to 37.6% during this period, although the difference did not reach significance, whereas there was no noticeable change over time in the prevalence of diabetes.Additionally, the prevalence of poor diet quality decreased from 76.1% to 67.8% from 2001-2004 to 2009-2012 but then increased to 71.7% in 2017-March 2020.Multicomponent behavior-changing interventions (e.g., increased physical activity [regardless of light or moderate-to-vigorous intensity], reduced sedentary behavior, adequate sleep, and highquality diets) [59][60][61][62][63], in combination with improved parent support behaviors [64], could help ease the burden of overweight/obesity for this population.
Despite the increased overweight/obesity prevalence, there was a gradual decrease in the prevalence of hypertension, from 8.1% to 5.5%, with similar results seen in a sensitivity analysis using the older guidelines (from 4.8% to 3.0%).This decrease was consistent with that seen previous reports [65,66].Actually, obesity appears to be more relevant to wide pulse pressure rather than mean arterial pressure [67].The contrary trends may be partly explained by reduced lead exposure acting on small resistance arteries, improved screening programs, and earlier pharmacologic or lifestyle interventions such as increased physical activity, smoking cessation, and sodium restriction [68][69][70][71][72].The prevalence of inactive physical activity significantly decreased from 83.0% to 9.5%, as did the prevalence of cigarette use (from 18.0% to 3.5%, although the difference was not statistically significant).Hyperlipidemia also showed a relative decrease of -33.3% over the past two decades, possibly due to reduced levels of trans-fatty acids in the food supply and a decline in smoking prevalence [73,74].These findings suggest that interventions targeting hypertension, hyperlipidemia, cigarette use, and physical activity have been more effective in comparison to interventions targeting overweight/obesity, prediabetes/diabetes, and diet quality.In light of the strong association between CVRFs and target organ damage during adolescence, as well as premature cardiovascular morbidity and mortality during adulthood, our data support the need for strengthening public health planning and individualized clinical interventions [5,[11][12][13][14][15][16][17][18][19].
Considerable disparities exist regarding the prevalence rates and trends of CVRFs across different sex and racial/ ethnic groups.On the one hand, boys were consistently at higher risk for hypertension, elevated BP, prediabetes, hyperlipidemia, cigarette use, and poor diet quality; however, on the other hand, boys were at lower risk for inactive physical activity.Men presented a similar risk for the aforementioned CVRFs compared to women as boys were to girls, and were more likely to experience severe adverse events (e.g., myocardial infarction, stroke, heart failure, and cardiovascular death) [75][76][77].The exact mechanisms underlying such inequalities are not fully understood, but are likely influenced by differences in inherent physiology, anti-inflammatory immune profiles, sex steroid hormone levels, and lifestyles (e.g., sodium intake) [78,79].Thus, it is necessary to adopt more effective strategies that consider sex differences in the management of CVRFs.
Unlike other races/ethnicities, non-Hispanic Blacks experienced a significant increase in diabetes, which may partly be attributed to early-life exposures, education, availability of services, and other factors potentially related to structural racism [80].Planning future efforts to address and mitigate these inequalities across racial/ethnic groups should be prioritized in the management of CVRFs among US adolescents.Besides, a clinically relevant increase in overweight/obesity prevalence was observed in Mexican Americans during the study period, which was generally consistent with previous reports [48,49].While disparities in overweight/obesity between Mexican Americans and non-Hispanic Whites used to be specific to US-born Mexican Americans, the disparities have expanded to non-USborn Mexican Americans over recent years [81].Possible reasons include the recent and rapid nutrition transition, changing selection migration dynamics, and longer time to live in the US [82][83][84].However, in contrast to the increase in obesity, Mexican Americans, together with non-Hispanic Whites, had a significant decrease in hyperlipidemia.Further studies are needed to explore the contributing factors for the fluctuation.
Throughout the survey period, hypertension treatment rate remained low (< 15%), albeit this may be partly explained by earlier lifestyle modifications.In a retrospective study including 15,422 children (aged 3-17 years) with BP equal to or greater than 95th percentile, 14,841 (96.2%) children sought lifestyle counseling, whereas 831 (5.4%) children received antihypertensive medications, and 848 (5.5%) children received BP-related referrals [85].Approximately 75% of adolescents receiving antihypertensive medications achieved BP targets at both the start and end of study period.When using the older guidelines, the proportions of adolescents who received antihypertensive medications or who achieved BP targets were substantially higher (varying between 8.0%-28.3%and 79.9%-100.0%,respectively).Meanwhile, diabetes treatment rates ranged from 26.5% to 72.1%, with no significant difference found during the study period.There was an upward trend in glycemic control rates (from 11.8% to 62.7%), although the difference was not statistically significant.A consistent screening, treatment, and monitoring program for adolescents is curial to ensure that they are receiving the best care available.

Limitations
This study has several limitations.First, misclassification of elevated BP/hypertension, prediabetes/diabetes, and hyperlipidemia may have existed due to the use of selfreported diagnoses and dependence on single-occasion physical examination or laboratory testing, possibly leading to an overestimation of CVRF prevalence among adolescents.Second, recommendations for the definition of hypertension and target BP levels have changed over the entire study period, resulting in a higher prevalence of hypertension and lower treatment and control rates.Third, we assessed risk factor treatment and control relying only on medication use, without considering lifestyle modifications such as salt-reduced diets and aerobic exercise, which are usually taken prior to pharmacologic therapy.Fourth, during 2001-2006, physical activity levels were underestimated due to a lack of data on home/yard tasks for adolescents aged 12-15 years and a lack of time data on muscle-strengthening activities across the age spectrum.Additionally, because data on weekly exercise time for participants aged 12-17 years were not available during 2017-March 2020, estimates only represented those aged 18-19 years throughout this period, potentially underestimating the prevalence of inactive physical inactivity.Fifth, the response rates for the NHANES have declined over time.Sixth, although the combination of two continuous NHANES cycles improved the reliability of prevalence estimates, the study may not have had sufficient statistical power to detect small changes in population subgroups with limited sample sizes.Finally, a proportion of nonpregnant participants (n = 368) were excluded because of insufficient clinical information.As the sample differed slightly from the included population and between survey years in terms of baseline characteristics, this study may not have been completely free of selection bias (Additional file 1: eTables 7-8).However, the proportion of missing data was low (≈ 2.4%); therefore, exclusion of the sample were not expected to significantly affect the results.

Conclusions
Over the past 2 decades, despite an increase in prediabetes and overweight/obesity, hypertension, hyperlipidemia, cigarette use, and inactive physical activity decreased among US adolescents aged 12 to 19 years, while elevated BP, diabetes, and poor diet quality remained unchanged.There were disparities in the prevalence of and trends in CVRFs across sociodemographic subpopulations.While treatment rates for hypertension and diabetes did not improve over time, BP control remained relatively stable, and there were numerical improvements in glycemic control.

(
See figure on next page.)Fig. 1 Age-Adjusted Trends in the Prevalence of Hypertension, Elevated BP, Diabetes, Prediabetes, Hyperlipidemia, Obesity, Overweight, Cigarette Use, Inactive Physical Activity, and Poor Diet Quality Among US Adolescents Aged 12 to 19 Years, 2001 to March 2020 a−i .Abbreviations: BP Blood pressure, CI Confidence interval.a Nationally representative estimates of US adolescents aged 12-19 years from the 2001-March 2020 National Health and Nutrition Examination Survey.Whiskers indicate 95% CIs.P for trend was calculated by the Joinpoint Regression Program: P = .04for hypertension in panel A; P = .73for elevated BP in panel B; P = .46for diabetes in panel C; P = .08for prediabetes in panel D; P = .01for hyperlipidemia in panel E; P = .002for obesity in panel F; P = .004for overweight in panel G; P = .07for cigarette use in panel H; P = .01for inactive physical activity in panel I; and P = .13for poor diet quality in panel J. Specific estimates are presented in Additional file 1: eTable 4. b

Fig. 2
Fig. 2 Age-Adjusted Trends in the Rates of Hypertension and Diabetes Treatment and Control Among US Adolescents Aged 12 to 19 Years, 2001 to March 2020 a−d .Abbreviations: BP Blood pressure, CI Confidence interval.a Nationally representative estimates of US adolescents aged 12-19 years from the 2001-March 2020 National Health and Nutrition Examination Survey.Whiskers indicate 95% CIs.P for trend was calculated by the Joinpoint Regression Program: P = .79for hypertension treatment and P = .60for diabetes treatment in panel A; P = .66for BP control and P value was not applicable for glycemic control in panel B. Specific estimates are presented in Additional file 1: eTable 4. b All estimates were age-standardized to the 2000 Census population using the age groups of 12 to 14, 15 to 17, and 18 to 19 years.c Hypertension treatment was defined as current use of antihypertensive medications and was evaluated among adolescents with hypertension (n = 901).Diabetes treatment was defined as current use of antidiabetic medications and was evaluated among adolescents with diabetes (n = 84).d Control was evaluated among adolescents receiving treatment (n = 68 for hypertension and n = 40 for diabetes).Hypertension was considered controlled if (1) BP was reduced to < 90th percentile in adolescents aged < 13 years, (2) BP was reduced to < 90th percentile and < 130/80 mmHg in adolescents aged 13-17 years, or (3) BP was reduced to < 130/80 mmHg in adolescents aged 18-19 years.Diabetes was considered controlled if hemoglobin A 1c was reduced to < 7%

Table 1 (
continued) < 130 31.1 (27.9-34.3)28.5 (24.9-32.0)32.3 (26.9-37.6)31.0 (26.3-35.8)29.2 (25.8-32.7).92130-349 36.4 (34.1-38.6)35.8 (32.5-39.2) 36.4 (31.9-40.9)39.2 (35.1-43.2) 37.4 (34.0-40.7).25 ≥ 350 32.5 (29.1-35.9)35.7 (31.1-40.4)31.3 (26.0-36.6)29.8 (24.9-34.7)33.4 (29.3-37.5).43 Nationally representative estimates of US adolescents aged 12-19 years from the 2001-March 2020 NHANES.The sample size for each 4-year interval was unweighted, whereas all other numbers were weighted means or percentages with 95% CIs Race/ethnicity was based on self-report.The non-Hispanic Asian category was not available before 2011 due to the survey design, and thus estimates could not be presented separately.All other racial/ethnic groups were grouped as 'Other' e Body mass index was missing for 394 (2.6%) participants among 15,155 included from the examination sample [42]onversions: to convert glucose to mmol/L, multiply by 0.0555; TC, HDL-C, non-HDL-C, and LDL-C to mmol/L, multiply by 0.0259; triglycerides to mmol/L, multiply by 0.0113 Abbreviations: CI Confidence interval, FPG Fasting plasma glucose, HDL-C High-density lipoprotein cholesterol, HEI-2015 Healthy Eating Index-2015, LDL-C Low-density lipoprotein cholesterol, NHANES National Health and Nutrition Examination Survey, non-HDL-C Non-high-density lipoprotein cholesterol, TC Total cholesterol a b Unweighted sample size c F test based on weighted linear regression or Wald test based on logistic regression d j Weekly exercise time was calculated as the minutes of moderate-intensity physical activity plus twice the minutes of vigorous-intensity physical activity per week.During 2001-2006, physical activity levels were underestimated due to a lack of data on home/yard tasks for adolescents aged 12-15 years and a lack of time data on muscle-strengthening activities across the age spectrum; data on weekly exercise time for participants aged 12-17 years were not available during 2017-March 2020, and thus estimates only represented those aged 18-19 years throughout this period.Weekly exercise time was missing for 5050 (33.3%) participants among 15,155 included from the examination sample k HEI-2015 was missing for 292 (2.0%) participants among 14,526 included from the dietary day one sample l Diet quality (ideal, intermediate, and poor) was based on Ref[42]

Table 2
Age-Adjusted Prevalence of Cardiovascular Risk Factors by Subgroups Among US Adolescents Aged 12 to 19 Years, 2001 to March 2020 a of ≥ 6.5%, fasting plasma glucose of ≥ 126 mg/dL, self-report of previous diagnosis, and/or current use of antidiabetic medications, whereas prediabetes was defined as a hemoglobin A was defined as a weekly exercise time of < 420 and < 150 min/wk in adolescents aged < 18 and 18-19 years, respectively.Weekly exercise time was calculated as the minutes of moderate-intensity physical activity plus twice the minutes of vigorous-intensity physical activity per week.During 2001-2006, physical activity levels were underestimated due to a lack of data on home/yard tasks for adolescents aged 12-15 years and a lack of time data on muscle-strengthening activities across the age spectrum; data on weekly exercise time for participants aged 12-17 years were not available during 2017-March 2020, and thus estimates only represented those aged 18-19 years throughout this period Abbreviations: BP Blood pressure, CI Confidence interval a Nationally representative estimates of US adolescents aged 12-19 years from the 2001-March 2020 National Health and Nutrition Examination Survey b All estimates were age-standardized to the 2000 Census population using the age groups of 12 to 14, 15 to 17, and 18 to 19 years c Hypertension was defined as stage 1 or 2 levels and/or current use of antihypertensive medications, whereas elevated BP was defined as an elevated level (see Ref. [33, 34]) d Diabetes was defined as a hemoglobin A 1c e Hyperlipidemia was defined as a total cholesterol of ≥ 200 mg/dL, high-density lipoprotein cholesterol of < 40 mg/dL, non-high-density lipoprotein cholesterol of f Obesity and overweight were defined based on body mass index using the Lambda Mu Sigma method (see Ref [38]) g Cigarette use was defined as smoking cigarettes within the previous 30 days h Inactive physical activity i Poor diet quality was defined as a Healthy Eating Index-2015 score of < 51 points j Unweighted number of cases and sample size kRace/ethnicity was based on self-report.The non-Hispanic Asian category was not available before 2011 due to the survey design, and thus estimates could not be presented separately.All other racial/ethnic groups were grouped as 'Other'

Table 3
Adjusted ORs for Cardiovascular Risk Factors by Subgroups Among US Adolescents Aged 12 to 19 Years, 2001 to March 2020 a Weekly exercise time was calculated as the minutes of moderate-intensity physical activity plus twice the minutes of vigorous-intensity physical activity per week.During 2001-2006, physical activity levels were underestimated due to a lack of data on home/yard tasks for adolescents aged 12-15 years and a lack of time data on muscle-strengthening activities across the age spectrum; data on weekly exercise time for participants aged 12-17 years were not available during 2017-March 2020, and thus estimates only represented those aged 18-19 years throughout this period [38]34]ations: BP Blood pressure, CI Confidence interval, OR Odds ratio a Nationally representative estimates of US adolescents aged 12-19 years from the 2001-March 2020 National Health and Nutrition Examination Survey.Adjusted ORs with 95% CIs were adjusted for age, sex, and race/ethnicity groups bHypertension was defined as stage 1 or 2 levels and/or current use of antihypertensive medications, whereas elevated BP was defined as an elevated level (see Ref[33,34]) c Diabetes was defined as a hemoglobin A e Obesity and overweight were defined based on body mass index using the Lambda Mu Sigma method (see Ref[38]) f Cigarette use was defined as smoking cigarettes within the previous 30 days g Inactive physical activity was defined as a weekly exercise time of < 420 and < 150 min/wk in adolescents aged < 18 and 18-19 years, respectively.h Poor diet quality was defined as a Healthy Eating Index-2015 score of < 51 points i Unweighted number of cases and sample size j Race/ethnicity was based on self-report.The non-Hispanic Asian category was not available before 2011 due to the survey design, and thus estimates could not be presented separately.All other racial/ethnic groups were grouped as 'Other'